Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.

@article{Richards2013GenePO,
  title={Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.},
  author={Kristy L Richards and Alison A. Motsinger-Reif and Hsiao-Wei T. Chen and Yuri Fedoriw and Cheng Fan and Dahlia M. Nielsen and George W Small and Rachael Thomas and Chris Smith and Sandeep S Dave and Charles M. Perou and Matthew Breen and Luke B. Borst and Steven E. Suter},
  journal={Cancer research},
  year={2013},
  volume={73 16},
  pages={5029-39}
}
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) are needed. Canine DLBCL, one of the most common cancers in veterinary oncology, is morphologically similar to hDLBCL and is treated using similar chemotherapeutic protocols. With genomic technologies, it is now possible to molecularly evaluate dogs as… CONTINUE READING
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Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell on April 15, 2017

  • G Salles, D de Jong, W Xie, A Rosenwald, M Chhanabhai, P Gaulard
  • Author Manuscript Published OnlineFirst on June
  • 2013
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