Gene products that promote mRNA turnover in Saccharomyces cerevisiae.

  title={Gene products that promote mRNA turnover in Saccharomyces cerevisiae.},
  author={P Leeds and Jennifer M Wood and B S Lee and Michael R. Culbertson},
  journal={Molecular and cellular biology},
  volume={12 5},
We showed previously that the increased rate of mRNA turnover associated with premature translational termination in the yeast Saccharomyces cerevisiae requires a functional UPF1 gene product. In this study, we show that the UPF1 gene codes for a 109-kDa primary translation product whose function is not essential for growth. The protein contains a potential zinc-dependent nucleic acid-binding domain and a nucleoside triphosphate-binding domain. A 300-amino-acid segment of the UPF1 protein is 36… CONTINUE READING
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