Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division

  title={Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division},
  author={Ruth Kiro and S. Molshanski-Mor and Ido Yosef and Sara L. Milam and H. Erickson and U. Qimron},
  journal={Proceedings of the National Academy of Sciences},
  pages={19549 - 19554}
  • Ruth Kiro, S. Molshanski-Mor, +3 authors U. Qimron
  • Published 2013
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance We have identified a phage-encoded inhibitor of the major cytoskeletal protein in bacterial division. The inhibition is shown to confer T7 bacteriophage with a significant growth advantage in dividing hosts. Our studies thus indicate a strategy in bacteriophages to maximize their progeny number by inhibiting escape of one of the daughter cells of an infected bacterium. Bacteriophages take over host resources primarily via the activity of proteins expressed early in infection. One… CONTINUE READING
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