Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division.

@article{Kiro2013GeneP0,
  title={Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division.},
  author={Ruth Kiro and Shahar Molshanski-Mor and Ido Yosef and Sara L. Milam and Harold P Erickson and Udi Qimron},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 48},
  pages={
          19549-54
        }
}
Bacteriophages take over host resources primarily via the activity of proteins expressed early in infection. One of these proteins, produced by the Escherichia coli phage T7, is gene product (Gp) 0.4. Here, we show that Gp0.4 is a direct inhibitor of the E. coli filamenting temperature-sensitive mutant Z division protein. A chemically synthesized Gp0.4 binds to purified filamenting temperature-sensitive mutant Z protein and directly inhibits its assembly in vitro. Consequently, expression of… CONTINUE READING

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