Gene prediction with a hidden Markov model and a new intron submodel

@article{Stanke2003GenePW,
  title={Gene prediction with a hidden Markov model and a new intron submodel},
  author={Mario Stanke and Stephan Waack},
  journal={Bioinformatics},
  year={2003},
  volume={19 Suppl 2},
  pages={ii215-25}
}
MOTIVATION The problem of finding the genes in eukaryotic DNA sequences by computational methods is still not satisfactorily solved. Gene finding programs have achieved relatively high accuracy on short genomic sequences but do not perform well on longer sequences with an unknown number of genes in them. Here existing programs tend to predict many false exons. RESULTS We have developed a new program, AUGUSTUS, for the ab initio prediction of protein coding genes in eukaryotic genomes. The… CONTINUE READING
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