Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with antiphospholipid antibodies.

@article{Yasuda2002GenePO,
  title={Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with antiphospholipid antibodies.},
  author={Shinsuke Yasuda and Akito Tsutsumi and Tatsuya Atsumi and Maria Laura Bertolaccini and Kenji Ichikawa and Munther A. Khamashta and GrahamR. V. Hughes and Toshio Koike},
  journal={The Journal of rheumatology},
  year={2002},
  volume={29 6},
  pages={
          1192-7
        }
}
OBJECTIVE Impaired fibrinolytical outcomes may be one of the pathogenic factors for thrombotic events in patients with antiphospholipid antibodies (aPL). We investigated the consequences of the gene polymorphisms of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) in patients positive for aPL. METHODS Seventy-seven Japanese and 82 British patients with aPL were examined for Alu-repeat insertion (I)/deletion (D) polymorphism of the tPA gene by polymerase chain… CONTINUE READING

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