Gene polymorphisms of the mu opioid receptor in methamphetamine abusers.

  title={Gene polymorphisms of the mu opioid receptor in methamphetamine abusers.},
  author={Soichiro Ide and Hideaki Kobayashi and Keiko Tanaka and Hiroshi Ujike and Yoshimoto Sekine and Norio Ozaki and Toshiya Inada and Mutsuo Harano and Tokutaro Komiyama and Mitsuhiko Yamada and Masaomi Iyo and Kazutaka Ikeda and Ichiro Sora},
  journal={Annals of the New York Academy of Sciences},
In drug addiction, the opioid system is thought to mediate motivational effects through dopamine-independent mechanisms. We have investigated associations of the mu-opioid receptor gene (OPRM) variations with methamphetamine (MAP) dependence/psychosis. The allelic frequency of A118G (Asn40Asp) in exon 1 of ORPM was 45.3% in our control subjects, but only 7.5-25.8% in the Caucasian or African-American population of previous studies. We have identified several novel polymorphisms in intron 1 and… CONTINUE READING
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