Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly

  title={Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly},
  author={Heike Koelsch and Michael Wagner and Andras Bilkei-Gorz{\'o} and Mohammad Reza Toliat and Michael Pentzek and Angela Fuchs and Hanna Kaduszkiewicz and Hendrik van den Bussche and Steffi G Riedel-Heller and Matthias Claus Angermeyer and Siegfried Weyerer and Jochen Werle and Horst Bickel and Edelgard Moesch and Birgitt Wiese and Moritz Daerr and Frank Jessen and Wolfgang Maier and Martin Dichgans},
  journal={Journal of Neural Transmission},
Cognitive functions show large variation in elderly people and are substantially heritable. Animal studies revealed that dynorphins influence cognition and memory, especially in aged animals. Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 ± 3.39 years; range 75–90 years) recruited through the… CONTINUE READING
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