Gene polymorphism but not catalytic activity of angiotensin I-converting enzyme is associated with coronary artery disease and myocardial infarction in low-risk patients.

@article{Gardemann1995GenePB,
  title={Gene polymorphism but not catalytic activity of angiotensin I-converting enzyme is associated with coronary artery disease and myocardial infarction in low-risk patients.},
  author={Andreas Gardemann and Thomas Weiss and Ole Schwartz and A Eberbach and Norbert Katz and Friedrich W Hehrlein and Harald Tillmanns and Wolfgang Waas and Werner G Haberbosch},
  journal={Circulation},
  year={1995},
  volume={92 10},
  pages={2796-9}
}
BACKGROUND An insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene has been postulated to be associated with an increased risk of coronary artery disease (CAD) and myocardial infarction (MI). METHODS AND RESULTS In the present study, the effects of I/D gene polymorphism and of ACE activity on CAD and MI were investigated in 920 individuals who underwent coronary angiography for diagnostic purposes. In the total population and in all CAD and MI groups, a… CONTINUE READING

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