Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production.

@article{Braun1996GenePA,
  title={Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production.},
  author={Nikolai Braun and Uwe Michel and Bernd Peter Ernst and Roland Metzner and Andreas Bitsch and Frank S Weber and Peter Rieckmann},
  journal={Neuroscience letters},
  year={1996},
  volume={215 2},
  pages={75-8}
}
Tumor-necrosis-factor alpha (TNF-alpha) is a major mediator of the inflammatory immune response and may play an important role in the pathogenesis and progression of Multiple Sclerosis (MS). Increased TNF-alpha levels of cerebrospinal fluid (CSF) and peripheral blood were found in patients with chronic progressive MS and patients with acute relapses, but not in the stable form of the disease. Considering the association of different TNF-alpha alleles with diverse autoimmune diseases we… CONTINUE READING
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