Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC.

@article{Stephens1999GeneOS,
  title={Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC.},
  author={Richard Stephens and Roger Horton and Sean J. Humphray and Lee Rowen and John Trowsdale and Sebastian Beck},
  journal={Journal of molecular biology},
  year={1999},
  volume={291 4},
  pages={789-99}
}
We have mapped and sequenced the region immediately centromeric of the human major histocompatibility complex (MHC). A cluster of 13 genes/pseudogenes was identified in a 175 kb PAC linking the TAPASIN locus with the class II region. It includes two novel human genes (BING4 and SACM2L) and a thus far unnoticed human leucocyte antigen (HLA) class II pseudogene, termed HLA-DPA3. Analysis of the G+C content revealed an isochore boundary which, together with the previously reported telomeric… CONTINUE READING
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