Gene networks controlling early cerebral cortex arealization.

  title={Gene networks controlling early cerebral cortex arealization.},
  author={Antonello Mallamaci and Anastassia Stoykova},
  journal={The European journal of neuroscience},
  volume={23 4},
Early thalamus-independent steps in the process of cortical arealization take place on the basis of information intrinsic to the cortical primordium, as proposed by Rakic in his classical protomap hypothesis [Rakic, P. (1988)Science, 241, 170-176]. These steps depend on a dense network of molecular interactions, involving genes encoding for diffusible ligands which are released around the borders of the cortical field, and transcription factor genes which are expressed in graded ways throughout… CONTINUE READING
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