Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.

@article{Astuti2001GeneMI,
  title={Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.},
  author={Dewi Astuti and Farida Latif and Ashraf Dallol and Patricia L. M. Dahia and F. Easton Douglas and Emad George and F Sk{\"o}ldberg and Eystein Sverre Husebye and Charis Eng and Eamonn R. Maher},
  journal={American journal of human genetics},
  year={2001},
  volume={69 1},
  pages={
          49-54
        }
}
The pheochromocytomas are an important cause of secondary hypertension. Although pheochromocytoma susceptibility may be associated with germline mutations in the tumor-suppressor genes VHL and NF1 and in the proto-oncogene RET, the genetic basis for most cases of nonsyndromic familial pheochromocytoma is unknown. Recently, pheochromocytoma susceptibility has been associated with germline SDHD mutations. Germline SDHD mutations were originally described in hereditary paraganglioma, a dominantly… 

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