Gene mutations in apical hypertrophic cardiomyopathy.

  title={Gene mutations in apical hypertrophic cardiomyopathy.},
  author={Michael Arad and Manual Penas-Lado and Lorenzo Monserrat and Barry Joel Maron and Mark V Sherrid and Carolyn Y. Ho and Scott C Barr and Ahmad Karim and Timothy Olson and Mitsohiro Kamisago and Jonathan G Seidman and Christine E Seidman},
  volume={112 18},
BACKGROUND Nonobstructive hypertrophy localized to the cardiac apex is an uncommon morphological variant of hypertrophic cardiomyopathy (HCM) that often is further distinguished by distinct giant negative T waves and a benign clinical course. The genetic relationship between HCM with typical hypertrophic morphology versus isolated apical hypertrophy is incompletely understood. METHODS AND RESULTS Genetic cause was investigated in 15 probands with apical hypertrophy by DNA sequence analyses of… CONTINUE READING