Gene mutations in adult Japanese patients with dilated cardiomyopathy.

  title={Gene mutations in adult Japanese patients with dilated cardiomyopathy.},
  author={Masami Shimizu and Hidekazu Ino and Toshihiko Yasuda and Noboru Fujino and Katsuharu Uchiyama and Tomohito Mabuchi and Tetsuo Konno and Tomoya Kaneda and Takashi Fujita and Eiichi Masuta and Masahiro Katoh and A. Funada and Hiroshi Mabuchi},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  volume={69 2},
BACKGROUND Some patients with dilated cardiomyopathy (DCM) have mutations of the genes that encode sarcomeric or cytoskeletal proteins of cardiomyocytes, but the prevalence of these mutations in Japan remains unclear. METHODS AND RESULTS A group of 99 unrelated adult patients with DCM (familial n=27, sporadic n=72) were screened for the following genes: cardiac beta-myosin heavy chain, cardiac myosin-binding protein C (MYBPC3), regulatory and essential myosin light chains, alpha cardiac actin… CONTINUE READING
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