Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

@inproceedings{Zhu2017GeneMP,
  title={Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance},
  author={Yong-mei Zhu and P J Wang and Jin-yan Huang and Yun-Shuo Chen and Bing Chen and Yu-Jun Dai and Han Yan and Yi Jun Hu and Wen-Yan Cheng and T Ma and Sai-juan Chen and Y. C. Shen},
  booktitle={Journal of Translational Medicine},
  year={2017}
}
Cytogenetic aberrations and gene mutations have long been regarded as independent prognostic markers in AML, both of which can lead to misexpression of some key genes related to hematopoiesis. It is believed that the expression level of the key genes is associated with the treatment outcome of AML. In this study, we analyzed the clinical features and molecular aberrations of 560 newly diagnosed non-M3 AML patients, including mutational status of CEBPA, NPM1, FLT3, C-KIT, NRAS, WT1, DNMT3A, MLL… CONTINUE READING
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