Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

@article{Peinert2010GenemodifiedTC,
  title={Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen},
  author={Stefan Peinert and H Miles Prince and Preethi Mayura Guru and Michael Kershaw and Mark J Smyth and Joseph A. Trapani and Peter Gambell and Sean J Harrison and Andrew Mark Scott and Fiona Smyth and Phillip K Darcy and Kellie M. Tainton and Paul Neeson and D. Stuart Ritchie and Dirk H{\"o}nemann},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={678-686}
}
We have evaluated the carbohydrate antigen LewisY (LeY) as a potential target for T-cell immunotherapy of hematological neoplasias. Analysis of 81 primary bone marrow samples revealed moderate LeY expression on plasma cells of myeloma patients and myeloblasts of patients with acute myeloid leukemia (AML) (52 and 46% of cases, respectively). We developed a retroviral vector construct encoding a chimeric T-cell receptor that recognizes the LeY antigen in a major histocompatibility complex… CONTINUE READING

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