Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy

@article{Nixon2005GenemediatedRO,
  title={Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy},
  author={Alan J. Nixon and Jennifer L Haupt and David D. Frisbie and St{\'e}phane Morisset and C W Mcilwraith and Paul D. Robbins and Christopher H. Evans and S C. Ghivizzani},
  journal={Gene Therapy},
  year={2005},
  volume={12},
  pages={177-186}
}
Combination of growth factor gene-enhanced cartilage matrix synthesis with interleukin-1 receptor antagonist protein (IL-1Ra) abrogation of cartilage matrix degradation may reduce and possibly reverse cartilage loss in synovitis and osteoarthritis. The feasibility of cotransduction of synovial membrane with two such genes that may act on cartilage homeostasis was investigated in an in vitro coculture system. Cultured synoviocytes in monolayer were cotransduced with E1-deleted adenoviral vectors… CONTINUE READING