Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.

@article{Hupp1989GeneMO,
  title={Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.},
  author={K Hupp and David Siwarski and Beverly A Mock and J P Kin{\'e}t},
  journal={Journal of immunology},
  year={1989},
  volume={143 11},
  pages={3787-91}
}
The high affinity receptor for IgE (Fc epsilon RI) is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. The gamma-chains do share a region of high homology with the zeta-chain of the TCR. No homology has… CONTINUE READING