Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.

@article{Etienne2013GeneLA,
  title={Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.},
  author={Lucie Etienne and Beatrice H. Hahn and Paul M Sharp and Frederick A. Matsen and Michael Emerman},
  journal={Cell host & microbe},
  year={2013},
  volume={14 1},
  pages={85-92}
}
HIV-1 resulted from cross-species transmission of SIVcpz, a simian immunodeficiency virus that naturally infects chimpanzees. SIVcpz, in turn, is a recombinant between two SIV lineages from Old World monkeys. Lentiviral interspecies transmissions are partly driven by the evolution and capacity of viral accessory genes, such as vpx, vpr, and vif, to antagonize host antiviral factors, such as SAMHD1 and the APOBEC3 proteins. We show that vpx, which in other lentiviruses antagonizes SAMHD1, was… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 13 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…