Gene loss, protein sequence divergence, gene dispensability, expression level, and interactivity are correlated in eukaryotic evolution.

@article{Krylov2003GeneLP,
  title={Gene loss, protein sequence divergence, gene dispensability, expression level, and interactivity are correlated in eukaryotic evolution.},
  author={Dmitri M Krylov and Yuri I. Wolf and Igor B. Rogozin and Eugene V. Koonin},
  journal={Genome research},
  year={2003},
  volume={13 10},
  pages={
          2229-35
        }
}
Lineage-specific gene loss, to a large extent, accounts for the differences in gene repertoires between genomes, particularly among eukaryotes. We derived a parsimonious scenario of gene losses for eukaryotic orthologous groups (KOGs) from seven complete eukaryotic genomes. The scenario involves substantial gene loss in fungi, nematodes, and insects. Based on this evolutionary scenario and estimates of the divergence times between major eukaryotic phyla, we introduce a numerical measure, the… CONTINUE READING

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