Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.

  title={Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.},
  author={Glyn D. Palmer and Andr{\'e} Steinert and Arnulf Pascher and Elvire Gouze and Jean-Noel Gouze and Oliver B. Betz and Brian Johnstone and Christopher H. Evans and Steven C. Ghivizzani},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={12 2},
Adult mesenchymal stem cells (MSCs) have the capacity to differentiate into various connective tissues such as cartilage and bone following stimulation with certain growth factors. However, less is known about the capacity of these cells to undergo chondrogenesis when these proteins are delivered via gene transfer. In this study, we investigated chondrogenesis of primary, bone marrow-derived MSCs in aggregate cultures following genetic modification with adenoviral vectors encoding chondrogenic… CONTINUE READING


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