Gene inactivation study of gntE reveals its role in the first step of pseudotrisaccharide modifications in gentamicin biosynthesis.

@article{Kim2008GeneIS,
  title={Gene inactivation study of gntE reveals its role in the first step of pseudotrisaccharide modifications in gentamicin biosynthesis.},
  author={Jin-Yong Kim and Joo-won Suh and Suk-Ho Kang and Thi Thanh Huyen Phan and Si-Hyung Park and Hyung-Jin Kwon},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={372 4},
  pages={
          730-4
        }
}
A gene inactivation study was performed on gntE, a member of the gentamicin biosynthetic gene cluster in Micromonospora echinospora. Computer-aided homology analysis predicts a methyltransferase-related cobalamin-binding domain and a radical S-adenosylmethionine domain in GntE. It is also found that there is no gntE homolog within other aminoglycoside biosynthetic gene clusters. Inactivation of gntE was achieved in both M. echinospora ATCC 15835 and a gentamicin high-producer GMC106. High… CONTINUE READING
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H

  • R. D. Woodyer, G. Li
  • Zhao, W.A. van der Donk, New insight into the…
  • 2007
2 Excerpts

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin

  • G. Li R. D. Woodyer, H. Zhao, W. A. van der Donk
  • Chem . Commun .
  • 2007

T

  • J. Unwin, S. Standage, D. Alexander
  • Hosted Jr., A.C. Horan, E.M.H. Wellington, Gene…
  • 2004
1 Excerpt

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