Gene inactivation in Drosophiia mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre

@article{Schlossherr1994GeneII,
  title={Gene inactivation in Drosophiia mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre},
  author={J{\"o}rg Schlossherr and Harald Eggert and Renato Paro and S. Cr{\'e}mer and Robert Smail Jack},
  journal={Molecular and General Genetics MGG},
  year={1994},
  volume={243},
  pages={453-462}
}
In Drosophila position effect variegation and Polycomb-dependent regulation of homeotic gene expression are phenomena in which genes are inactivated in a clonally inherited manner. In both processes inactivation involves proteins that interact with the chromosome at or close to the position of inactivated genes. Two models have been proposed to explain this form of genetic silencing. In one, cooperative concatamerisation of a large multisubunit protein complex packages the chromatin fibre into… CONTINUE READING

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