Gene-gene and gene-environment interactions on IgE production in prenatal stage.

@article{Yang2010GenegeneAG,
  title={Gene-gene and gene-environment interactions on IgE production in prenatal stage.},
  author={Kuender D. Yang and J Chang and Hau Chuang and H-M Liang and Ho-Chang Kuo and Yun-Sang Lee and T-Y Hsu and C-Y Ou},
  journal={Allergy},
  year={2010},
  volume={65 6},
  pages={731-9}
}
BACKGROUND Prevalence of allergic diseases in children has increased worldwide over the past decades. Allergy sensitization may occur in fetal life. This study investigated whether gene-gene and gene-environment interactions affected cord blood IgE (CBIgE) levels. METHODS A total of 575 cord blood DNA samples were subjected to a multiplex microarray for 384 single nucleotide polymorphisms (SNPs) in 159 allergy candidate genes. Genetic association was initially assessed by univariate and… CONTINUE READING