Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.

@article{Kallberg2007GenegeneAG,
  title={Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.},
  author={Henrik J Kallberg and Leonid Padyukov and Robert M. Plenge and Johan Ronnelid and Peter K. Gregersen and Annette H van der Helm-van Mil and Ren{\'e} E. M. Toes and Tom W. J. Huizinga and Lars Klareskog and Lars Alfredsson},
  journal={American journal of human genetics},
  year={2007},
  volume={80 5},
  pages={867-75}
}
Gene-gene and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex diseases. The aim of this study was to use and compare three different definitions of interaction between the two major genetic risk factors of RA--the HLA-DRB1 shared epitope (SE) alleles and the PTPN22 R620W allele--in three large case-control studies: the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, the North American RA Consortium… CONTINUE READING