Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

@article{Barr2001GeneFI,
  title={Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma},
  author={F. G. Barr},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={5736-5746}
}
The chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) are characteristic of alveolar rhabdomyosarcoma, a pediatric soft tissue cancer related to the striated muscle lineage. These translocations rearrange PAX3 and PAX7, members of the paired box transcription factor family, and juxtapose these genes with FKHR, a member of the fork head transcription factor family. This juxtaposition generates PAX3–FKHR and PAX7–FKHR chimeric genes that are expressed as chimeric transcripts that… CONTINUE READING