Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line

@article{Alves2013GeneFB,
  title={Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line},
  author={Ines Teles Alves and Saskia D. Hiltemann and Thomas Hartjes and Peter J. van der Spek and Andrew Stubbs and Jan Trapman and Guido Jenster},
  journal={Human Genetics},
  year={2013},
  volume={132},
  pages={709-713}
}
The VCaP cell line is widely used in prostate cancer research as it is a unique model to study castrate resistant disease expressing high levels of the wild type androgen receptor and the TMPRSS2-ERG fusion transcript. Using next generation sequencing, we assembled the structural variations in VCaP genomic DNA and observed a massive number of genomic rearrangements along the q arm of chromosome 5, characteristic of chromothripsis. Chromothripsis is a recently recognized phenomenon characterized… CONTINUE READING