Gene function in mouse embryogenesis: get set for gastrulation

  title={Gene function in mouse embryogenesis: get set for gastrulation},
  author={Patrick P. L. Tam and David A. F. Loebel},
  journal={Nature Reviews Genetics},
During early mouse embryogenesis, temporal and spatial regulation of gene expression and cell signalling influences lineage specification, embryonic polarity, the patterning of tissue progenitors and the morphogenetic movement of cells and tissues. Uniquely in mammals, the extraembryonic tissues are the source of signals for lineage specification and tissue patterning. Here we discuss recent discoveries about the lead up to gastrulation, including early manifestations of asymmetry, coordination… 

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