Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.

@article{Croce1985GeneFA,
  title={Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.},
  author={Carlo M. Croce and Masaharu Isobe and Antonio Palumbo and J Puck and Jia Ming and D Tweardy and Jan Erikson and Mary Lynne Davis and Giovanni Giacomo Rovera},
  journal={Science},
  year={1985},
  volume={227 4690},
  pages={1044-7}
}
A human complementary DNA clone specific for the alpha-chain of the T-cell receptor and a panel of rodent X human somatic cell hybrids were used to map the alpha-chain gene to human chromosome 14 in a region proximal to the immunoglobulin heavy chain locus. Analysis by means of in situ hybridization of human metaphase chromosomes served to further localize the alpha-chain gene to region 14q11q12, which is consistently involved in translocations and inversions detectable in human T-cell… CONTINUE READING

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