Gene family encoding the major toxins of lethal Amanita mushrooms.

@article{Hallen2007GeneFE,
  title={Gene family encoding the major toxins of lethal Amanita mushrooms.},
  author={Heather E Hallen and Hong Luo and John S. Scott-Craig and Jonathan D. Walton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 48},
  pages={19097-101}
}
Amatoxins, the lethal constituents of poisonous mushrooms in the genus Amanita, are bicyclic octapeptides. Two genes in A. bisporigera, AMA1 and PHA1, directly encode alpha-amanitin, an amatoxin, and the related bicyclic heptapeptide phallacidin, a phallotoxin, indicating that these compounds are synthesized on ribosomes and not by nonribosomal peptide synthetases. alpha-Amanitin and phallacidin are synthesized as proproteins of 35 and 34 amino acids, respectively, from which they are predicted… CONTINUE READING
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