Gene expression variation in Down's syndrome mice allows prioritization of candidate genes

Abstract

Down's syndrome (DS), or trisomy 21, is a complex developmental disorder that exhibits many clinical signs that vary in occurrence and severity among patients. The molecular mechanisms responsible for DS have thus far remained elusive. We argue here that normal variation in gene expression in the population contributes to the heterogeneous clinical picture… (More)
DOI: 10.1186/gb-2007-8-5-r91

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