Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer

@inproceedings{Companioni2017GeneES,
  title={Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer},
  author={Osmel Companioni and Jos{\'e} Miguel Sanz-Anquela and Mar{\'i}a Luisa Pardo and Eul{\`a}lia Puigdecanet and Lara Nonell and Nadia Garcia and Ver{\'o}nica Parra Blanco and Consuelo Lopez and Victoria Andreu and Miriam Cuatrecasas and Maddi Garmendia and Javier P Gisbert and Carlos A. Gonz{\'a}lez and N{\'u}ria Sala},
  booktitle={PloS one},
  year={2017}
}
BACKGROUND Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM, and also from IM subtypes to GC. METHODOLOGY We used expression data to compare the transcriptome of healthy gastric mucosa to that of IM not… CONTINUE READING