Gene expression signatures in neutrophils exposed to glucocorticoids: a new paradigm to help explain "neutrophil dysfunction" in parturient dairy cows.

@article{Burton2005GeneES,
  title={Gene expression signatures in neutrophils exposed to glucocorticoids: a new paradigm to help explain "neutrophil dysfunction" in parturient dairy cows.},
  author={Jeanne L Burton and Sally A Madsen and L. B. Chang and Patty Sue Weber and Kelly R Buckham and Renate van Dorp and Mary-Clare Hickey and Bernadette Earley},
  journal={Veterinary immunology and immunopathology},
  year={2005},
  volume={105 3-4},
  pages={197-219}
}
Neutrophils are the first line of immunity against most pathogens that infect cattle. These normally short-lived white blood cells develop from myeloid-lineage cells in bone marrow. Upon maturation, bone marrow neutrophils are released into the circulation where they marginate on inflamed blood vessel endothelial cells and migrate through them into the area of infection. Once migrated, neutrophils do not reenter the circulation, but rather, perform their bactericidal functions and die by… CONTINUE READING

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