Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition.

@article{Tanabe2014GeneES,
  title={Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition.},
  author={Shihori Tanabe and Kazuhiko Aoyagi and Hiroshi Yokozaki and Hiroki Sasaki},
  journal={International journal of oncology},
  year={2014},
  volume={44 6},
  pages={1955-70}
}
Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy. The hedgehog-EMT pathway is preferentially activated in diffuse-type gastric cancer (GC) compared with intestinal-type GC; however, histological typing is currently the only method for distinguishing these two major types of GC. We compared the gene expression profiles of 12 bone marrow-derived mesenchymal stem cell cultures and 5 diffuse-type GC tissue samples. Numerous upregulated or downregulated genes were… CONTINUE READING
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