Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis.

Abstract

We performed gene-expression profiling of PBMCs obtained from patients with familial hemophagocytic lymphohistiocytosis (FHL) to screen for biologic correlates with the genetic and/or clinical forms of this disease. Unsupervised hierarchical clustering of 167 differentially expressed probe sets, representing 143 genes, identified 3 groups of patients… (More)
DOI: 10.1182/blood-2012-05-425769

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