Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.

  title={Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.},
  author={Javeed Iqbal and George Wright and Chao Wang and Andreas Rosenwald and Randy D. Gascoyne and Dennis D. Weisenburger and Timothy C. Greiner and Lynette M. Smith and Shuangping Guo and Ryan A Wilcox and Bin Tean Teh and Soon Thye Lim and Soon Yong Tan and Lisa M Rimsza and Elaine S. Jaffe and El{\'i}as Campo and Antonio Olivas Martinez and Jan Delabie and Rita M. Braziel and James R Cook and Raymond R. Tubbs and German Ott and E Geissinger and Philippe Gaulard and Pier Paolo Piccaluga and Stefano A Pileri and Wing-yan Au and Shigeo Nakamura and Masao Seto and Françoise Berger and Laurence de Leval and Joseph M. Connors and James Olen Armitage and Julie Marie Vose and Wing Chung Chan and Louis M. Staudt},
  volume={123 19},
Peripheral T-cell lymphoma (PTCL) encompasses a heterogeneous group of neoplasms with generally poor clinical outcome. Currently 50% of PTCL cases are not classifiable: PTCL-not otherwise specified (NOS). Gene-expression profiles on 372 PTCL cases were analyzed and robust molecular classifiers and oncogenic pathways that reflect the pathobiology of tumor cells and their microenvironment were identified for major PTCL-entities, including 114 angioimmunoblastic T-cell lymphoma (AITL), 31… CONTINUE READING
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