Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells.

@article{Khalid2014GeneES,
  title={Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells.},
  author={Omar Khalid and Jeffrey J Kim and Hyun-Sung Kim and Michael C. Hoang and Thanh G. Tu and Omid Elie and Connie Lee and Catherine Vu and Steve Horvath and Igor Spigelman and Yong Kim},
  journal={Stem cell research},
  year={2014},
  volume={12 3},
  pages={791-806}
}
Stem cells, especially human embryonic stem cells (hESCs), are useful models to study molecular mechanisms of human disorders that originate during gestation. Alcohol (ethanol, EtOH) consumption during pregnancy causes a variety of prenatal and postnatal disorders collectively referred to as fetal alcohol spectrum disorders (FASDs). To better understand the molecular events leading to FASDs, we performed a genome-wide analysis of EtOH's effects on the maintenance and differentiation of hESCs in… CONTINUE READING

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