Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome

@article{Kyng2005GeneER,
  title={Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome},
  author={Kasper J Kyng and Alfred J. May and Tinna Stevnsner and Kevin G. Becker and Steen K\olvr{\aa} and Vilhelm A. Bohr},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={5026-5042}
}
The accumulation of DNA damage and mutations is considered a major cause of cancer and aging. While it is known that DNA damage can affect changes in gene expression, transcriptional regulation after DNA damage is poorly understood. We characterized the expression of 6912 genes in human primary fibroblasts after exposure to three different kinds of cellular stress that introduces DNA damage: 4-nitroquinoline-1-oxide (4NQO), γ-irradiation, or UV-irradiation. Each type of stress elicited damage… CONTINUE READING

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