Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis.

@article{Kishimoto2004GeneER,
  title={Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis.},
  author={Yosuke Kishimoto and Soji Fukumoto and Sumi Nishihara and Hiroyuki Mizumura and Kazumitsu Hirai and Ryota Teshima},
  journal={Rheumatology},
  year={2004},
  volume={43 12},
  pages={1496-503}
}
OBJECTIVES To investigate gene expression relevant to osteoclastogenesis in the synovium and bone marrow during the development of collagen-induced arthritis (CIA) in mature rats. METHODS Total messenger RNAs (mRNAs) were obtained from CIA synovium and bone marrow after immunization. First, reverse transcriptase-polymerase chain reactions (RT-PCR) were carried out to detect the mRNA encoding receptor activator of NF-kappaB (RANK), RANK ligand (RANKL), osteoprotegerin (OPG), tumour necrosis… CONTINUE READING
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