Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy.

@article{Beard2013GeneEP,
  title={Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy.},
  author={Rachel E. Beard and Daniel Abate-Daga and Shannon F Rosati and Zhili Zheng and John R. Wunderlich and Steven A Rosenberg and Richard A. Morgan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 18},
  pages={4941-50}
}
PURPOSE The success of immunotherapy for the treatment of metastatic cancer is contingent on the identification of appropriate target antigens. Potential targets must be expressed on tumors but show restricted expression on normal tissues. To maximize patient eligibility, ideal target antigens should be expressed on a high percentage of tumors within a histology and, potentially, in multiple different malignancies. DESIGN A Nanostring probeset was designed containing 97 genes, 72 of which are… CONTINUE READING
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