Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells

@inproceedings{Bowen2009GeneEP,
  title={Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells},
  author={Nathan Bowen and L. DeEtte Walker and Lilya V. Matyunina and Sanjay Logani and Kimberly A Totten and Benedict B. Benigno and John F McDonald},
  booktitle={BMC Medical Genomics},
  year={2009}
}
Accumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been hypothesized to arise from at least two possible classes of progenitor cells: the ovarian surface epithelia (OSE) and/or an as yet undefined class of progenitor cells residing in the distal end of the fallopian tube. Comparative gene expression profiling analyses were carried out on OSE removed from the surface of… CONTINUE READING