Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes.

@article{Mense2006GeneEP,
  title={Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes.},
  author={Sarah M. Mense and Aniruddha Sengupta and M Zhou and Cathy Lan and Galina Bentsman and David J. Volsky and Li Zhong Zhang},
  journal={Physiological genomics},
  year={2006},
  volume={25 3},
  pages={435-49}
}
Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular levels, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain; thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. Here, we used microarray gene expression profiling and data… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

Comparative study of gene set enrichment methods

BMC Bioinformatics • 2008
View 7 Excerpts
Highly Influenced

Identification of regulatory regions of bidirectional genes in cervical cancer

BMC Medical Genomics • 2013
View 2 Excerpts
Highly Influenced

Comparative Response of Brain to Chronic Hypoxia and Hyperoxia

International journal of molecular sciences • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 148 references

PI 3-kinase, Akt and cell survival.

Seminars in cell & developmental biology • 2004
View 13 Excerpts
Highly Influenced

Cell cycle and apoptosis.

View 13 Excerpts
Highly Influenced

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

International journal of oncology • 2003
View 13 Excerpts
Highly Influenced

Signaling networks that link cell proliferation and cell fate.

The Journal of biological chemistry • 2002
View 13 Excerpts
Highly Influenced

The role of epidermal growth factor and its receptors in mammalian CNS.

Cytokine & growth factor reviews • 2004
View 15 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…