Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

  title={Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts},
  author={Elisabetta A Renzoni and David J. Abraham and Sarah L Howat and Xu Shi-wen and Piersante Sestini and George Bou-Gharios and Athol U Wells and Srihari Veeraraghavan and Andrew G. Nicholson and Christopher P. Denton and Andrew Leask and Jeremy D. Pearson and Carol Mary Black and Kenneth I. Welsh and Roland M du Bois},
  journal={Respiratory Research},
  pages={24 - 24}
BACKGROUND Transforming growth factor beta (TGFbeta), a multifunctional cytokine, plays a crucial role in the accumulation of extracellular matrix components in lung fibrosis, where lung fibroblasts are considered to play a major role. Even though the effects of TGFbeta on the gene expression of several proteins have been investigated in several lung fibroblast cell lines, the global pattern of response to this cytokine in adult lung fibroblasts is still unknown. METHODS We used Affymetrix… CONTINUE READING
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