Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles.

@article{Kedziorek2010GeneEP,
  title={Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles.},
  author={Dorota A. Kedziorek and Naser Muja and Piotr Walczak and Jes{\'u}s Ru{\'i}z-Cabello and Assaf A. Gilad and Chunfa C. Jie and Jeff W M Bulte},
  journal={Magnetic resonance in medicine},
  year={2010},
  volume={63 4},
  pages={1031-43}
}
With MRI (stem) cell tracking having entered the clinic, studies on the cellular genomic response toward labeling are warranted. Gene expression profiling was applied to C17.2 neural stem cells following superparamagnetic iron oxide/PLL (poly-L-lysine) labeling over the course of 1 week. Relative to unlabeled cells, less than 1% of genes (49 total) exhibited greater than 2-fold difference in expression in response to superparamagnetic iron oxide/PLL labeling. In particular, transferrin receptor… CONTINUE READING

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