Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts.

@article{Vengellur2003GeneEP,
  title={Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts.},
  author={Ajith Vengellur and Barbara G Woods and Heather E. Ryan and Randall S Johnson and John J Lapres},
  journal={Gene expression},
  year={2003},
  volume={11 3-4},
  pages={
          181-97
        }
}
Hypoxia is defined as a deficiency of oxygen reaching the tissues of the body, and it plays a critical role in development and pathological conditions, such as cancer. Once tumors outgrow their blood supply, their central portion becomes hypoxic and the tumor stimulates angiogenesis through the activation of the hypoxia-inducible factors (HIFs). HIFs are transcription factors that are regulated in an oxygen-dependent manner by a group of prolyl hydroxylases (known as PHDs or HPHs). Our… CONTINUE READING

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