Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

@article{Grnblatt2004GeneEP,
  title={Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes},
  author={Edna Gr{\"u}nblatt and Sivia Mandel and Jasmine Jacob-Hirsch and Sharon Zeligson and N. Amariglo and Gideon Rechavi and Jie Li and Rivka Ravid and Wolfgang Roggendorf and Peter Franz Riederer and Moussa B. H. Youdim},
  journal={Journal of Neural Transmission},
  year={2004},
  volume={111},
  pages={1543-1573}
}
Gene expression profiling of human substantia nigra pars compacta (SNpc) from Parkinson’s disease (PD) patients, was examined employing high density microarrays. We identified alterations in the expression of 137 genes, with 68 down regulated and 69 up regulated. The down regulated genes belong to signal transduction, protein degradation (e.g. ubiquitin-proteasome subunits), dopaminergic transmission/metabolism, ion transport, protein modification/phosphorylation and energy pathways/glycolysis… CONTINUE READING
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