Gene expression profiling of ovine keratinocytes stimulated with Psoroptes ovis mite antigen--a preliminary study.

@article{Watkins2009GeneEP,
  title={Gene expression profiling of ovine keratinocytes stimulated with Psoroptes ovis mite antigen--a preliminary study.},
  author={Craig A. Watkins and Anne Mackellar and David J. Frew and Claire E. Mackie and Alvin M. George and John Hopkins and Stewart T. G. Burgess and Tom N McNeilly and John F. Huntley},
  journal={Parasite immunology},
  year={2009},
  volume={31 6},
  pages={304-11}
}
Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antigens. The kinetics of the mRNA response of these cells were monitored by microarray. The results indicated that the cells responded within 1 h of challenge, with a significant… CONTINUE READING

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