Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells.

@article{Tenedini2004GeneEP,
  title={Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells.},
  author={Elena Tenedini and Maria Elena Fagioli and Nicola Vianelli and Pier Luigi Tazzari and Francesca Ricci and Enrico Tagliafico and Paolo Emilio Ricci and Luigi Gugliotta and Giovanni Martinelli and Sante Tura and Michele Baccarani and Sergio Ferrari and Lucia Catani},
  journal={Blood},
  year={2004},
  volume={104 10},
  pages={
          3126-35
        }
}
Gene expression profiles of bone marrow (BM) CD34-derived megakaryocytic cells (MKs) were compared in patients with essential thrombocythemia (ET) and healthy subjects using oligonucleotide microarray analysis to identify differentially expressed genes and disease-specific transcripts. We found that proapoptotic genes such as BAX, BNIP3, and BNIP3L were down-regulated in ET MKs together with genes that are components of the mitochondrial permeability transition pore complex, a system with a… CONTINUE READING

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