Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.

@article{Glaser2003GeneEP,
  title={Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.},
  author={Keith B. Glaser and Michael J. Staver and Jeffrey F. Waring and Joshua D Stender and Roger G. Ulrich and Steven K. Davidsen},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 2},
  pages={151-63}
}
Acetylation of histones in chromatin is one mechanism involved in the regulation of gene transcription and is tightly controlled by the balance of acetyltransferase and deacetylase (HDAC) activities. In cancer, some genes are repressed by the inappropriate recruitment of HDACs, e.g., tumor suppressor genes. To understand the genomic effects of HDAC inhibition on gene transcription we studied the gene expression profiles of T24 bladder and MDA breast carcinoma cells treated with three HDAC… CONTINUE READING
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