Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays.

@article{Huang2000GeneEP,
  title={Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays.},
  author={Herv{\'e} Huang and Stefano Colella and Michael Odo Kurrer and Yasuhiro Yonekawa and Paul Kleihues and Hiroko Ohgaki},
  journal={Cancer research},
  year={2000},
  volume={60 24},
  pages={6868-74}
}
Diffuse astrocytoma WHO grade II is a well-differentiated, slowly growing tumor that has an inherent tendency to progress to anaplastic astrocytoma (WHO grade III) and, eventually, to glioblastoma (WHO grade IV). Little is known about its molecular basis, except for p53 mutations that are found in >60% of cases. In a search for additional genetic alterations, we carried out gene expression profiling of 11 diffuse astrocytomas using cDNA expression arrays. Expression of six genes (TIMP3, c-myc… CONTINUE READING

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